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RHYTHM PHARMACEUTICALS, INC.

RYTM · CIK 0001649904

SEC FORM 4
$302,500.00

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 50,000 shares at $6.05 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code M

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$655,145.07

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 6,439 shares at $101.7464 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code S

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$3,146,760.86

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 30,746 shares at $102.347 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code S

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$899,634.14

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 8,698 shares at $103.43 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code S

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$189,964.99

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 1,817 shares at $104.5487 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code S

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$241,937.00

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 2,300 shares at $105.19 per share.

Reporting Person Meeker David P · Officer Title President and CEO · Transaction Code S

Traded Sep 14, 2026 · Disclosed Sep 14, 2026

Source: SEC Form 4 · 0001649904-26-000026 · filed 2026-09-14 · View filing →

SEC FORM 4
$1,474,852.73

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 57,187 shares at $25.79 per share.

Reporting Person Smith Hunter C · Officer Title Chief Financial Officer · Transaction Code M

Traded Aug 31, 2026 · Disclosed Sep 1, 2026

Source: SEC Form 4 · 0001649904-26-000023 · filed 2026-09-01 · View filing →

SEC FORM 4
$2,413,033.57

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 23,072 shares at $104.5871 per share.

Reporting Person Smith Hunter C · Officer Title Chief Financial Officer · Transaction Code S

Traded Aug 31, 2026 · Disclosed Sep 1, 2026

Source: SEC Form 4 · 0001649904-26-000023 · filed 2026-09-01 · View filing →

SEC FORM 4
$1,213,232.48

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 11,514 shares at $105.3702 per share.

Reporting Person Smith Hunter C · Officer Title Chief Financial Officer · Transaction Code S

Traded Aug 31, 2026 · Disclosed Sep 1, 2026

Source: SEC Form 4 · 0001649904-26-000023 · filed 2026-09-01 · View filing →

SEC FORM 4
$2,993,647.35

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 28,188 shares at $106.2029 per share.

Reporting Person Smith Hunter C · Officer Title Chief Financial Officer · Transaction Code S

Traded Aug 31, 2026 · Disclosed Sep 1, 2026

Source: SEC Form 4 · 0001649904-26-000023 · filed 2026-09-01 · View filing →

SEC FORM 4
$233,031.37

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 2,007 shares at $116.1093 per share.

Reporting Person Garfield Alastair · Officer Title Chief Scientific Officer · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000013 · filed 2026-08-17 · View filing →

SEC FORM 4
$182,170.10

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 1,556 shares at $117.0759 per share.

Reporting Person Garfield Alastair · Officer Title Chief Scientific Officer · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000013 · filed 2026-08-17 · View filing →

SEC FORM 4
$402,166.62

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 3,400 shares at $118.2843 per share.

Reporting Person Garfield Alastair · Officer Title Chief Scientific Officer · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000013 · filed 2026-08-17 · View filing →

SEC FORM 4
$95,335.04

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 800 shares at $119.1688 per share.

Reporting Person Garfield Alastair · Officer Title Chief Scientific Officer · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000013 · filed 2026-08-17 · View filing →

SEC FORM 4
$13,763.20

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 2,024 shares at $6.80 per share.

Reporting Person Shulman Joseph · Officer Title Chief Technical Officer · Transaction Code M

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000015 · filed 2026-08-17 · View filing →

SEC FORM 4
$608,210.25

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 5,079 shares at $119.75 per share.

Reporting Person Shulman Joseph · Officer Title Chief Technical Officer · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 17, 2026

Source: SEC Form 4 · 0001649904-26-000015 · filed 2026-08-17 · View filing →

SEC FORM 4
$850,150.00

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 35,000 shares at $24.29 per share.

Reporting Person Lee Jennifer Kayden · Officer Title EVP, Head of North America · Transaction Code M

Traded Aug 13, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000009 · filed 2026-08-14 · View filing →

SEC FORM 4
$146,886.80

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 21,601 shares at $6.80 per share.

Reporting Person Lee Jennifer Kayden · Officer Title EVP, Head of North America · Transaction Code M

Traded Aug 13, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000009 · filed 2026-08-14 · View filing →

SEC FORM 4
$8,901,531.42

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 75,834 shares at $117.3818 per share.

Reporting Person Lee Jennifer Kayden · Officer Title EVP, Head of North America · Transaction Code S

Traded Aug 13, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000009 · filed 2026-08-14 · View filing →

SEC FORM 4
$317,050.00

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Acquisition (code M) of 46,625 shares at $6.80 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code M

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$257,138.16

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 2,300 shares at $111.7992 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$112,856.00

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 1,000 shares at $112.856 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$413,477.28

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 3,605 shares at $114.6955 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$1,681,540.54

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 14,568 shares at $115.427 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$2,121,124.57

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 18,208 shares at $116.4941 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →

SEC FORM 4
$2,034,438.68

RHYTHM PHARMACEUTICALS, INC. (RYTM)

Sale of 17,319 shares at $117.4686 per share.

Reporting Person Mazabraud Yann · Officer Title EVP, Head of International · Transaction Code S

Traded Aug 12, 2026 · Disclosed Aug 14, 2026

Source: SEC Form 4 · 0001649904-26-000007 · filed 2026-08-14 · View filing →